Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Identifieur interne : 003733 ( Main/Exploration ); précédent : 003732; suivant : 003734Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Auteurs : Renate Lüllmann-Rauch [Allemagne] ; Brigitte Stoermer [Allemagne]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1982-12-01.
Descripteurs français
- KwdFr :
- Animaux, Chloroquine, Chlorphentermine, Cochons d'Inde, Femelle, Foie (ultrastructure), Glandes surrénales (ultrastructure), Grossesse, Hypophyse (ultrastructure), Hypothalamus (ultrastructure), Lignées consanguines de rats, Lipidoses (), Microscopie électronique, Moelle spinale (ultrastructure), Phentermine (analogues et dérivés), Pipérazines, Poumon (ultrastructure), Rate (ultrastructure), Rats, Rein (ultrastructure), Échange foetomaternel.
- MESH :
- analogues et dérivés : Phentermine.
- Animaux, Chloroquine, Chlorphentermine, Cochons d'Inde, Femelle, Foie, Glandes surrénales, Grossesse, Hypophyse, Hypothalamus, Lignées consanguines de rats, Lipidoses, Microscopie électronique, Moelle spinale, Pipérazines, Poumon, Rate, Rats, Rein, Échange foetomaternel.
English descriptors
- KwdEn :
- Adrenal Glands (ultrastructure), Animals, Chlorcyclizine, Chloroquine, Chlorphentermine, Experimental lipidosis, Female, Guinea Pigs, Guinea pig, Hypothalamus (ultrastructure), Kidney (ultrastructure), Lipidoses (chemically induced), Liver (ultrastructure), Lung (ultrastructure), Maternal-Fetal Exchange, Microscopy, Electron, Phentermine (analogs & derivatives), Piperazines, Pituitary Gland (ultrastructure), Pregnancy, Prenatal development, Rat, Rats, Rats, Inbred Strains, Spinal Cord (ultrastructure), Spleen (ultrastructure).
- MESH :
- chemical , analogs & derivatives : Phentermine.
- chemically induced : Lipidoses.
- ultrastructure : Adrenal Glands, Hypothalamus, Kidney, Liver, Lung, Pituitary Gland, Spinal Cord, Spleen.
- Teeft :
- Abnormal lamellar inclusions, Abnormal lamellated inclusions, Adrenal, Adrenal cortex, Adrenal medulla, Adult animals, Adult rats, Adult tissues, Altromin gmbh, Alveolar epithelial cells, Alveolar macrophages, Amphiphilic, Amphiphilic drugs, Animal species, Animals, Anterior horn perikarya, Cell pathol, Cell tissue, Cellular factors, Chlorcyclizine, Chlorcyclizine treatment, Chloroquine, Chloroquine treatment, Chloroquine treatments, Chlorphentermine, Chlorphentermine administration, Chlorphentermine treatment, Control newborns, Corresponding mothers, Drinking water, Epithelial cells, Female, Fetal, Fetal lipidosis, Fetal tissues, Ganglion cells, General organization, Generalized lipidosis, Granulated cells, Guinea, Guinea Pigs, Guinea pigs, Higher magnification, Inclusion, Inclusion bodies, Initial body weight, Inset, Kupffer cells, Lamellar, Lamellar inclusions, Lamellated, Lamellated inclusions, Lamellated material, Lesser degree, Lipidosis, Little alteration, Little effect, Liver tissues, Lysosomal apparatus, Macrophage, Many macrophages, Maternal-Fetal Exchange, Medulla, Microglial, Microglial cells, Microscopy, Electron, Nerve cells, Nervous system, Neurosecretory perikarya, Newborn, Newborn animals, Newborn controls, Newborn guinea, Newborn rats, Perikarya, Piperazines, Polar lipids, Polymorphous osmiophilic material, Posterior horn, Pregnancy, Pregnant animals, Prenatal development, Proximal tubule, Rat, Rats, Rats, Inbred Strains, Significant lipidosis, Slight alterations, Spinal cord, Stomach tube, Subcutaneous injection, Treatment periods, Ultrastructure, Virchows arch, Zona fasciculata.
Abstract
Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.
Url:
DOI: 10.1007/BF02892837
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Glands (ultrastructure)</term>
<term>Animals</term>
<term>Chlorcyclizine</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Experimental lipidosis</term>
<term>Female</term>
<term>Guinea Pigs</term>
<term>Guinea pig</term>
<term>Hypothalamus (ultrastructure)</term>
<term>Kidney (ultrastructure)</term>
<term>Lipidoses (chemically induced)</term>
<term>Liver (ultrastructure)</term>
<term>Lung (ultrastructure)</term>
<term>Maternal-Fetal Exchange</term>
<term>Microscopy, Electron</term>
<term>Phentermine (analogs & derivatives)</term>
<term>Piperazines</term>
<term>Pituitary Gland (ultrastructure)</term>
<term>Pregnancy</term>
<term>Prenatal development</term>
<term>Rat</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Spinal Cord (ultrastructure)</term>
<term>Spleen (ultrastructure)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Cochons d'Inde</term>
<term>Femelle</term>
<term>Foie (ultrastructure)</term>
<term>Glandes surrénales (ultrastructure)</term>
<term>Grossesse</term>
<term>Hypophyse (ultrastructure)</term>
<term>Hypothalamus (ultrastructure)</term>
<term>Lignées consanguines de rats</term>
<term>Lipidoses ()</term>
<term>Microscopie électronique</term>
<term>Moelle spinale (ultrastructure)</term>
<term>Phentermine (analogues et dérivés)</term>
<term>Pipérazines</term>
<term>Poumon (ultrastructure)</term>
<term>Rate (ultrastructure)</term>
<term>Rats</term>
<term>Rein (ultrastructure)</term>
<term>Échange foetomaternel</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Phentermine</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Phentermine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Lipidoses</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Adrenal Glands</term>
<term>Hypothalamus</term>
<term>Kidney</term>
<term>Liver</term>
<term>Lung</term>
<term>Pituitary Gland</term>
<term>Spinal Cord</term>
<term>Spleen</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Abnormal lamellar inclusions</term>
<term>Abnormal lamellated inclusions</term>
<term>Adrenal</term>
<term>Adrenal cortex</term>
<term>Adrenal medulla</term>
<term>Adult animals</term>
<term>Adult rats</term>
<term>Adult tissues</term>
<term>Altromin gmbh</term>
<term>Alveolar epithelial cells</term>
<term>Alveolar macrophages</term>
<term>Amphiphilic</term>
<term>Amphiphilic drugs</term>
<term>Animal species</term>
<term>Animals</term>
<term>Anterior horn perikarya</term>
<term>Cell pathol</term>
<term>Cell tissue</term>
<term>Cellular factors</term>
<term>Chlorcyclizine</term>
<term>Chlorcyclizine treatment</term>
<term>Chloroquine</term>
<term>Chloroquine treatment</term>
<term>Chloroquine treatments</term>
<term>Chlorphentermine</term>
<term>Chlorphentermine administration</term>
<term>Chlorphentermine treatment</term>
<term>Control newborns</term>
<term>Corresponding mothers</term>
<term>Drinking water</term>
<term>Epithelial cells</term>
<term>Female</term>
<term>Fetal</term>
<term>Fetal lipidosis</term>
<term>Fetal tissues</term>
<term>Ganglion cells</term>
<term>General organization</term>
<term>Generalized lipidosis</term>
<term>Granulated cells</term>
<term>Guinea</term>
<term>Guinea Pigs</term>
<term>Guinea pigs</term>
<term>Higher magnification</term>
<term>Inclusion</term>
<term>Inclusion bodies</term>
<term>Initial body weight</term>
<term>Inset</term>
<term>Kupffer cells</term>
<term>Lamellar</term>
<term>Lamellar inclusions</term>
<term>Lamellated</term>
<term>Lamellated inclusions</term>
<term>Lamellated material</term>
<term>Lesser degree</term>
<term>Lipidosis</term>
<term>Little alteration</term>
<term>Little effect</term>
<term>Liver tissues</term>
<term>Lysosomal apparatus</term>
<term>Macrophage</term>
<term>Many macrophages</term>
<term>Maternal-Fetal Exchange</term>
<term>Medulla</term>
<term>Microglial</term>
<term>Microglial cells</term>
<term>Microscopy, Electron</term>
<term>Nerve cells</term>
<term>Nervous system</term>
<term>Neurosecretory perikarya</term>
<term>Newborn</term>
<term>Newborn animals</term>
<term>Newborn controls</term>
<term>Newborn guinea</term>
<term>Newborn rats</term>
<term>Perikarya</term>
<term>Piperazines</term>
<term>Polar lipids</term>
<term>Polymorphous osmiophilic material</term>
<term>Posterior horn</term>
<term>Pregnancy</term>
<term>Pregnant animals</term>
<term>Prenatal development</term>
<term>Proximal tubule</term>
<term>Rat</term>
<term>Rats</term>
<term>Rats, Inbred Strains</term>
<term>Significant lipidosis</term>
<term>Slight alterations</term>
<term>Spinal cord</term>
<term>Stomach tube</term>
<term>Subcutaneous injection</term>
<term>Treatment periods</term>
<term>Ultrastructure</term>
<term>Virchows arch</term>
<term>Zona fasciculata</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Cochons d'Inde</term>
<term>Femelle</term>
<term>Foie</term>
<term>Glandes surrénales</term>
<term>Grossesse</term>
<term>Hypophyse</term>
<term>Hypothalamus</term>
<term>Lignées consanguines de rats</term>
<term>Lipidoses</term>
<term>Microscopie électronique</term>
<term>Moelle spinale</term>
<term>Pipérazines</term>
<term>Poumon</term>
<term>Rate</term>
<term>Rats</term>
<term>Rein</term>
<term>Échange foetomaternel</term>
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<front><div type="abstract" xml:lang="en">Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
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<settlement><li>Kiel</li>
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<tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name>
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<name sortKey="Stoermer, Brigitte" sort="Stoermer, Brigitte" uniqKey="Stoermer B" first="Brigitte" last="Stoermer">Brigitte Stoermer</name>
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